/ / Siofor 850 - instructions

Siofor 850 - instruction

Currently, there are a lot of drugs used in the treatment of diabetes.

Siofor 850 - instruction

The drug "Siofor 850" (Siofor) isoblong tablets, covered with a white sheath, which have a bilateral incision for division. The manufacturer is Berlin-Chemie AG. Produced in a cardboard pack of 60 tablets.

Composition: 1 tablet of this drug contains 850 mg of metformin hydrochloride and additional substances: hypromellose; povidone; macrogol 6000; titanium; magnesium stearate.

Pharmacological actions.

"Siofor 850" is a hypoglycemic drug. The mechanism of action is due to its ability to reduce gluconeogenesis and the formation of fatty acids. It does not affect the amount of insulin in the blood, but as a result of the action it changes its pharmacodynamics. In the mechanism of action of metformin, it is important to stimulate the absorption of glucose by the muscles. It increases blood flow in the liver and the conversion of glucose into glycogen, improving the fibrinolytic properties of the blood.

Indications for use:
- insulin-independent diabetes mellitus, especially when combined with obesity.


- with complete cessation of insulin secretion in the body with insulin-dependent diabetes mellitus;
- insulin-dependent diabetes mellitus;
- diabetic ketoacidosis, precoma or coma;
- impaired renal or hepatic function;
- myocardial infarction;
- Diseases of the respiratory system;
- severe cases of an infectious disease;
- heart failure;
- surgery, trauma;
- hypoxic conditions;
- lactation (breastfeeding);
- Pregnancy;
- chronic alcoholism;
- childhood;
- an allergic reaction to the components of the drug.

Doses and methods of application.

The dosage of the preparation "Siofor 850" and the duration of application is set by the doctor individually for each patient, depending on the blood glucose level. The maximum dose is 3 g.

You need to take it without chewing while eating and drink with any liquid. In case the appointed daily dose is more than 1 tab, it must be divided into 3 doses.

Manifestations of side effects: allergic reactions to the skin, diarrhea, abdominal pain, mouthfeel, metal anorexia, nausea, vomiting, development of megaloblastic anemia.

special instructions

Patients over 65 years of age should be prescribed a Siofor 850with extreme caution. Before appointing a drug, it is necessary to monitor the function and kidney of the liver. For 2 days before the X-ray examination with the introduction of contrast agents or surgery, it is necessary to replace "Siofor" with another hypoglycemic drug.

During the use of the drug, because of the high risk of developing hypoglycemia, it is not recommended to engage in activities that require rapid psychomotor reactions and attention.

Symptoms of overdose: diarrhea, severe weakness, nausea, vomiting, muscle pain, abdominal pain, rapid breathing and loss of consciousness; there is the possibility of developing hypoglycemia, which is accompanied by tachycardia, pallor of the skin, a feeling of hunger, trembling, increased sweating.

Drug Interactions

The hypoglycemic effect of the drug is enhancedwhen it is taken with other drugs of hypoglycemic action, salicylates, ACE inhibitors, oxytetracycline. It is possible to reduce hypoglycemic action when taking thyroid hormones, contraceptives, glucocorticoids, oral nicotinic acid derivatives, diuretics and sympathomimetics simultaneously,
When taking a syophore together with indirect anticoagulants, it is necessary to monitor the clotting parameters of the blood.

Storage conditions: store in a place protected from light at room temperature.

About the drug "Siofor 850" reviews of doctors and patients are mostly positive.